Post-doc Design and synthesis of Enzyme Inhibitors

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Using your experience in small-molecule organic synthesis, you will design and synthesise new heterocyclic molecules that are able to inhibit PDE enzymes. You will synthesise, isolate and characterize novel drug-like molecules. Your compounds will be screened for enzyme inhibition, enabling the development of structure-activity relationships that guide the synthesis of additional compounds. 

The candidate will join a well-integrated, multidisciplinary team and work closely with colleagues who conduct Computer-Aided Drug Design (CADD) studies and biological screening. The results are expected to lead to publications in high-quality scientific journals, while also contributing to the specific goal of developing new medicines for Alzheimer’s disease.

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