PhD fellowship in solid state Pharmacy at the Department of Pharmacy

PhD fellowship in solid state Pharmacy at the Department of Pharmacy

Project Description

Poor aqueous solubility is one of the greatest unsolved challenges in modern drug development, affecting more than 90% of small‑molecule drug candidates and severely limiting their therapeutic potential. While crystalline drug forms provide physical stability, their poor solubility often compromises bioavailability and clinical performance. Amorphous drug forms can overcome this limitation by dramatically enhancing solubility; however, their inherent instability and tendency to recrystallize remain major barriers to their widespread application.

This project seeks to challenge conventional paradigms in pharmaceutical formulation by pioneering new concepts in “amorphous engineering”. Recent breakthroughs from our group have demonstrated that drugs can exist in multiple amorphous forms and/or polyamorphs, with distinct physicochemical properties. This largely unexplore...